Disturbances in hormonal status due to acne

Propionibacterium microorganism is anaerobic (without air breeds), so
the number of closed comedones it increases significantly. The
bacteria P. acnes synthesize various so-called chemoattractant
substances that attract to the site of accumulation of protective
cells released by bacteria and enzymes damage the protective cell wall
of the follicle. As a result of rupture of the content of the dermis
gets in there and causes an inflammatory response. Acne No More Review

Disturbances in hormonal status - In the skin, there is a large amount
of hormone-dependent structures. An excessive level of androgen (male
hormone) stimulates the proliferation of skin cells and sebum
hyperproduction. Estrogens (female hormones) have the opposite effect.
Progesterone and estrogen precursor has a stimulating effect on the
sebaceous gland. This explains the appearance of acne elements in the
second half to the female menstrual cycle, and when the amount of
progesterone is maximized.

Violation of the secretion of the sebaceous glands and the composition
of sebum - Normally, sebum is composed of two components directly
sebaceous lipids synthesized and epidermal cells. Excessive amounts of
sebum and violation in the direction of reducing the lipid content of
epidermal origin contributes to hyperkeratosis of the mouth of the
output channel causing it to clog. Mike Walden Acne No More Review

Reducing the content of polyunsaturated fatty acids in the sebum
reduces its ability to bind free radicals which appear under the
action of ultraviolet rays and cause destructive changes in the skin.
The resulting products have a comedogenic effect.